Breast Cancer
Scientists at Shanghai Medical College Detail Research in Breast Cancer
Published in Cancer Weekly, February 14th, 2012
2012 FEB 14 -- A report, "Germline genetic variants disturbing the Let-7/LIN28 double-negative feedback loop alter breast cancer susceptibility," is newly published data in Plos Genetics. According to the authors of recent research from Shanghai, People's Republic of China, "Previous studies have shown that let-7 can repress the post-transcriptional translation of LIN28, and LIN28 in turn could block the maturation of let-7, forming a double-negative feedback loop. In this study, we investigated the effect of germline genetic variants on regulation of the homeostasis of the let-7/LIN28 loop and breast cancer risk."
"We initially demonstrated that the...
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Source: Cancer Weekly (2012-02-14)
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