Colon Cancer

Studies from P. Alhopuro et al in the Area of Colon Cancer Described

Published in Cancer Weekly, March 6th, 2012

2012 MAR 6 -- According to the authors of recent research from Barcelona, Spain, "Defects in the mismatch repair system lead to microsatellite instability (MSI), a feature observed in similar to 15% of all colorectal cancers (CRCs). Microsatellite mutations that drive tumourigenesis, typically inactivation of tumour suppressors, are selected for and are frequently detected in MSI cancers."

"Here, we evaluated somatic mutations in microsatellite repeats of 790 genes chosen based on reduced expression in MSI CRC and existence of a coding mononucleotide repeat of 6 similar to 10 bp in length. All the repeats were initially sequenced in 30 primary MSI CRC...

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Source: Cancer Weekly (2012-03-06)

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