Hereditary Nonpolyposis Colorectal Cancer
Research from University of New South Wales Yields New Data on Hereditary Nonpolyposis Colorectal Cancer
Published in Cancer Weekly, March 6th, 2012
2012 MAR 6 -- Researchers detail in "Alu in Lynch syndrome: a danger SINE," new data in Hereditary Nonpolyposis Colorectal Cancer. According to the authors of a study from Sydney, Australia, "Lynch syndrome is a hereditary cancer predisposition syndrome caused by germline loss of a DNA mismatch repair gene. In a significant proportion of cases, loss of function of the MSH2 mismatch repair gene is caused by large heterogeneous deletions involving MSH2 and/or the adjacent EPCAM gene."
"These deletions usually result from homologous malrecombination events between Alu elements, a family of short interspersed nuclear elements (SINE). Recent recognition that the...
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Source: Cancer Weekly (2012-03-06)
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