General Science

New General Science Study Findings Have Been Published by Investigators at Oregon Health and Science University

Published in Cancer Weekly, March 20th, 2012

2012 MAR 20 -- "High expression of the oncoprotein Myc has been linked to poor outcome in human tumors. Although MYC gene amplification and translocations have been observed, this can explain Myc overexpression in only a subset of human tumors," scientists in Portland, Oregon report.

"Myc expression is in part controlled by its protein stability, which can be regulated by phosphorylation at threonine 58 (T58) and serine 62 (S62). We now report that Myc protein stability is increased in a number of breast cancer cell lines and this correlates with increased phosphorylation at S62 and decreased phosphorylation at T58. Moreover, we find this same shift in...

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Source: Cancer Weekly (2012-03-20)

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