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Microsatellite Instability

Researchers from Medical University Describe Findings in Microsatellite Instability

Published in Cancer Weekly, March 20th, 2012

2012 MAR 20 -- According to the authors of a study from Warsaw, Poland, "Backround: The aim of the present study was to assess the effect of dietary supplementation (copper or copper and resveratrol) on the intensity of carcinogenesis and the frequency of microsatellite instability in a widely used model of mammary carcinogenesis induced in the rat by treatment with 7,12-dimethylbenz[a] anthracene (DMBA). DNA was extracted from rat mammary cancers and normal tisues, amplified by PCR, using different polymorphic DNA markers and the reaction products were analyzed for microsatellite instability."

"It was found that irrespectively of the applied diet there was...

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