Apoptosis

Researchers from University of Colorado Describe Findings in Apoptosis

Published in Cancer Weekly, April 3rd, 2012

2012 APR 3 -- According to the authors of a study from Aurora, Colorado, "Better preventive strategies are required to reduce ultraviolet (UV)-caused photodamage, the primary etiological factor for non-melanoma skin cancer (NMSC). Accordingly, here we examined the preventive efficacy of silibinin against UVB-induced photodamage using mouse epidermal JB6 cells and SKH1 hairless mouse epidermis."

"In JB6 cells, silibinin pretreatment protected against apoptosis and accelerated the repair of cyclobutane pyrimidine dimers (CPD) induced by moderate dose of UVB (50 mJ/cm(2)), which we are at risk of daily exposure. Silibinin also reversed UVB-induced S phase...

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Source: Cancer Weekly (2012-04-03)

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