University of Manchester
ACE gene polymorphism linked to damage in Alzheimer disease
Published in Cardiovascular Business Week, March 30th, 2004
"The impact of the insertion/deletion (I/D) polymorphism in the angiotensin I-converting enzyme (ACE) gene on the extent of white matter myelin loss (ML) was investigated in four regions of the cerebral cortex in an autopsy-confirmed series of 93 patients with Alzheimer disease (AD). The possible influence of APO E epsilon4 allele acting in concert with ACE D allele was assessed. The extent of ML did not differ between D/D, I/D and I/I genotype groups when data from all four brain regions were combined," scientists in England...
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