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University of Michigan

Short-term weight loss improved metabolic syndrome in overweight adults

Published in Cardiovascular Business Week, June 29th, 2004

Short-term weight loss improved metabolic syndrome but not vascular endothelial function in overweight adults.

"Impaired vascular endothelial function may be an important mechanism linking obesity to increased cardiovascular risk. We investigated whether short-term weight loss improves conduit artery endothelial dysfunction in overweight adults. Forty-three otherwise healthy overweight patients with a body mass index {{>=}}30 kg/m2 completed an open-label 3-month trial consisting of a calorie-restricted diet and 120 mg of orlistat taken three times daily with meals," investigators in the United States report.

"Endothelial function and...

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