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Cardiovascular Business Week

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Chinese Academy of Science



PKC contributes to the cardioprotection afforded by intermittent hypoxia



December 7th, 2004

Intermittent hypoxia protects the rat heart against ischemia/reperfusion injury by activating protein kinase C.

Researchers in the People's Republic of China report, "The aim of [our] study was to investigate whether and how protein kinase C (PKC) was involved in the protection afforded by intermittent hypoxia (IH) and the subcellular distribution of different PKC isozymes in the rat left ventricle."

H.L. Ding and colleagues of the Chinese Academy of Science explained, "Post-ischemic recovery of left ventricular developed pressure and ±dP/dtmax in IH hearts were higher than those of normoxic hearts. Chelerythrine (CHE, 5 mcM), a PKC...


Source: Cardiovascular Business Week (2004-12-07)

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