Cardiovascular Business Week

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Case Western University

TnT may contribute to the higher tolerance of slow muscles to stress conditions

According to recent research published in the journal Archives of Biochemistry and Biophysics, "Troponin T (TnT) is an essential protein in the Ca²⁺ regulatory system of striated of muscle. Three fiber type-specific TnT genes have evolved in higher vertebrates to encode cardiac, slow and fast skeletal muscle TnT isoforms. To understand the functional significance of TnT isoforms, we studied the effects of acidosis on the contractility of transgenic mouse cardiac muscle that expresses fast skeletal muscle TnT."

T.M. Nosek and colleagues of Case...

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