Cardiovascular Business Week
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Evotec Technologies
Results contrast with the current perception of IL-6 receptor activation
April 26th, 2005
Researchers have investigated the dynamics of the gp130 cytokine complex and describe a model for assembly on the cellular membrane. According to researchers in Germany, "Cytokines of the interleukin-6 (IL-6)-type family all bind to the glycoprotein gp130 on the cell surface and require interaction with two gp130 or one gp130 and another related signal transducing receptor subunit. In addition, some cytokines of this family, such as IL-6, interleukin-11, ciliary neurotrophic factor, neuropoietin, cardiotrophin-1, and cardiotrophin-l-like-cytokine, interact with specific ligand binding receptor proteins." A. Schroers and colleagues of Evotec...
Source: Cardiovascular Business Week (2005-04-26)
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