Cardiovascular Business Week
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Cancer Research Center of Hawaii
Novel GAP-like protein examined, influence on connexin revealed
April 26th, 2005
According to published research from the United States, a novel rab GAP-like protein interacts with connexin and induces its degradation. "Gap junctions play critical roles in tissue function and homeostasis. Connexin43 (Cx43) is a major gap junction protein expressed in the mammalian heart and other tissues and may be regulated by its interaction with other cellular proteins. "Using the yeast two-hybrid screen, we identified a novel Cx43-interacting protein of 85-kDa, CIP85, which contains a single TBC, SH3, and RUN domain, in addition to a short-coiled coil region," wrote Z. Lan and colleagues, Cancer Research Center of Hawaii. ...
Source: Cardiovascular Business Week (2005-04-26)
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