Cardiovascular Business Week
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Burnham Institute, La Jolla
Plasma fibronectin guides angiostatic peptides to angiogenic vessels
April 26th, 2005
Plasma fibronectin guides angiostatic peptides to angiogenic vessels. "A group of angiogenesis inhibitors are derived from fragments of extracellular matrix or blood proteins. Endostatin, antithrombin, and anastellin are members of this group of substances. The plasma adhesion proteins fibronectin and vitronectin serve as cofactors for these three antiangiogenic proteins," scientists writing in the journal Proceedings of the National Academy of Sciences of the United States of America report. "Anginex is a synthetic 33-amino acid peptide that was originally modeled to reproduce the beta-sheet structure of antiangiogenic proteins. Here, we show...
Source: Cardiovascular Business Week (2005-04-26)
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