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Brigham & Women's Hospital, Boston
Absence of heme oxygenase-1 exacerbates myocardial injury in diabetic mice
April 26th, 2005
The absence of heme oxygenase-1 was found to exacerbate myocardial injury in a study of diabetic mice. "Increased production of reactive oxygen species contributes to the etiology of diabetes complications. Pathophysiological stimuli that increase oxidative stress upregulate heme oxygenase (HO)-1, a cytoprotective hemedegrading enzyme. We hypothesized that HO-1 may be important in myocardial injury that is exacerbated by diabetes," wrote X.L. Liu and colleagues at Brigham & Women's Hospital, Boston. "To test this hypothesis," they said, "the left anterior descending coronary arteries of nondiabetic and diabetic wild-type (HO-1+/+) and HO-1 null...
Source: Cardiovascular Business Week (2005-04-26)
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