Cardiovascular Business Week
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Baylor College of Medicine
Platelet glycoprotein-von Willebrand factor complex studied, effects shown
April 26th, 2005
According to a study from the United States, the platelet glycoprotein Ib-von Willebrand factor (VWF) interaction activates the collagen receptor alpha2beta1 to bind collagen. "Integrin alpha2beta1 (glycoprotein [GP] Ia/IIa) is a major platelet receptor for collagen, containing its collagen-binding site within the alpha2beta1 domain," wrote M.A. Cruz and colleagues, Baylor College of Medicine. "Alpha2beta1 changes conformation upon platelet activation, increasing its affinity for collagen. We observed that two antibodies known to bind within the alpha21 domain, 12F1 and 6F1, bound preferentially to adenosine diphosphate (ADP)-activated platelets....
Source: Cardiovascular Business Week (2005-04-26)
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