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Federal University of Rio de Janeiro
PI-PLC beta studied, role in angiotensin-mediated modulation demonstrated
April 26th, 2005
According to research from Brazil, PI-PLC beta is involved in the modulation of the proximal tubule Na+-ATPase by angiotensin II. "In previous papers we showed that Ang II increases the proximal tubule Na+-ATPase activity through AT1 /PKC pathway (L.B.A. Rangel, C. Caruso-Neves, L.S. Lara, A.G. Lopes, Angiotensin H stimulates renal proximal tubule Na+-ATPase activity through the activation of protein kinase C. Biochim. Biophys. Acta 1564 (2002) 310-316). "In the present paper," wrote L.B.A. Rangel and colleagues, Federal University of Rio de Janeiro, "we study the involvement of PI-PLCbeta on the stimulatory effect of...
Source: Cardiovascular Business Week (2005-04-26)
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