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Ain Shams University, Cairo

Probucol enhances antioxidant reserve and myocardial energy state

According to researchers in Egypt, "In [our] study, we examined whether the powerful antioxidant probucol (a clinically used lipid-lowering drug) would attenuate the oxidative stress and energy starvation in an experimental model of heart failure (HF) using isoproterenol."

E. El Demerdash and colleagues of Ain Shams University in Cairo explained, "Rats were injected subcutaneously with isoproterenol (2.4 mg kg^-1) daily for 1 week, and then treated with probucol (61 mg/kg) daily for 2 weeks. Oxidative stress was assessed by measuring...

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