Baylor University, U.S.
Cardiac outflow tract, pharyngeal arch development depend on mesodermal expression of Tbx1
Published in Cardiovascular Business Week, November 7th, 2006
According to recent research published in the journal Development, "The development of the segmented pharyngeal apparatus involves complex interaction of tissues derived from all three germ layers. The role of mesoderm is the least studied, perhaps because of its apparent lack of anatomical boundaries and positionally restricted gene expression."
"Here, we report that the mesoderm-specific deletion of Tbx1, a T-box transcription factor, caused severe pharyngeal patterning and cardiovascular defects, while mesoderm-specific...
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