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Ischemia Therapy

Researchers at University of Alberta, Faculty of Medicine and Dentistry target ischemia therapy

Published in Cardiovascular Business Week, November 21st, 2006

New research, "Effects of adenosine on myocardial glucose and palmitate metabolism after transient ischemia: role of 5'-AMP-activated protein kinase," is the subject of a report. According to recent research from Edmonton, Canada, "Loss of cardioprotection by adenosine in hearts stressed by transient ischemia may be due to its effects on glucose metabolism. In the absence of transient ischemia, adenosine inhibits glycolysis, whereas it accelerates glycolysis after transient ischemia."

"Inasmuch as 5'-AMP-activated protein kinase (AMPK) is implicated as a regulator of glucose and fatty acid utilization, this study determined whether a differential alteration of AMPK...

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