Antibacterial Agents

Pneumonia germ cell wall can damage heart, brain cells

Published in Cardiovascular Business Week, November 21st, 2006

Investigators at St. Jude Children's Research Hospital have discovered in mouse models how cell walls from certain pneumonia-causing bacteria can cause fatal heart damage, and they have shown how antibiotic therapy can actually make this damage worse by increasing the amount of cell wall pieces shed by dying bacteria.

The team demonstrated exactly how the fragmented cell wall pieces are able to latch onto the inner lining of blood vessels and "ferry" themselves through the vessel wall and out into the body.

However, the team used special drug-like molecules to successfully prevent the cell wall pieces from escaping from the blood vessels and entering...

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Source: Cardiovascular Business Week (2006-11-21)

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