Cardiomegaly
Scientists at Washington University, Center for Cardiovascular Research report research in cardiomegaly
Published in Cardiovascular Business Week, March 20th, 2007
Investigators publish new data in the report "Beta3 integrin deficiency promotes cardiac hypertrophy and inflammation. Cardiac hypertrophy commonly develops in response to pressure overload and is associated with increased mortality. Mechanical stress in the heart can result in the activation of transmembrane integrin alphabeta heterodimers that are expressed in cardiomyocytes," scientists in the United States report.
"Once activated, integrins stimulate focal adhesion kinase, Grb2, c-src, and other signaling molecules to promote cardiomyocyte growth and gene expression. Mechanical stress can also promote cardiac inflammation that may be mediated, in part, by the...
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