Sepsis
Research in the area of sepsis reported from Medizinische University Graz
Published in Cardiovascular Business Week, January 1st, 2008
Current study results from the report, 'Endotoxin impairs the human pacemaker current If,' have been published. "LPSs trigger the development of sepsis by gram-negative bacteria and cause a variety of biological effects on host cells, including alterations on ionic channels. Because heart rate variability is reduced in human sepsis and endotoxemia, we hypothesized that LPS affects the pacemaker current I(f) in human heart, which might--at least in part--explain this phenomenon," researchers in Graz, Austria report.
"Isolated human myocytes from right atrial appendages were incubated for 6 to 10 h with LPS (1 and 10 microg/mL) and afterwards used to investigate the...
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