Atherosclerosis
New atherosclerosis research from Yale University discussed
Published in Cardiovascular Business Week, February 12th, 2008
A new study, 'Phospholipase C beta3 deficiency leads to macrophage hypersensitivity to apoptotic induction and reduction of atherosclerosis in mice,' is now available. According to recent research published in the Journal of Clinical Investigation, "Atherosclerosis is an inflammatory disease that is associated with monocyte recruitment and subsequent differentiation into lipid-laden macrophages at sites of arterial lesions, leading to the development of atherosclerotic plaques. PLC is a key member of signaling pathways initiated by G protein-coupled ligands in macrophages."
"However, the role of this enzyme in the regulation of macrophage function is not known....
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