Enzyme Research
Study findings from School of Medicine broaden understanding of enzyme research
Published in Cardiovascular Business Week, March 25th, 2008
Researchers detail in 'Are primed polymorphonuclear leukocytes contributors to the high heparanase levels in hemodialysis patients,' new data in enzyme research. "Patients on chronic hemodialysis (HD) are at high risk for developing atherosclerosis and cardiovascular complications. Heparanase, an endoglycosidase that cleaves heparan sulfate (HS) side chains of proteoglycans, is involved in extracellular matrix degradation and, as such, may be involved in the atherosclerotic lesion progression," scientists in Haifa, Israel report.
"We hypothesize that heparanase is elevated in HD patients, partly due to its release from primed circulating polymorphonuclear leukocytes...
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