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Heart Attack

New drug targets for preventing cell death

Published in Cardiovascular Business Week, March 25th, 2008

A new compound that blocks an early step in cell death could lead to a novel class of drugs for treating heart attacks and stroke.

When cells are deprived of oxygen -- during a heart attack, for example -- they start to die through a tidy process called apoptosis or programmed cell death. Early in apoptosis, the mitochondria -- complex structures that supply energy to the cell -- divide into pieces, holes appear in their membranes and proteins such as cytochrome c leak out. These events trigger other processes, ending in cell death.

"Mitochondria divide like crazy during apoptosis," said Jodi Nunnari, professor of molecular and cellular biology at UC...

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