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Cardiomegaly

Scientists at University of Sao Paulo target cardiomegaly

Published in Cardiovascular Business Week, May 6th, 2008

"Kallikrein-kinin system exerts cardioprotective effects against pathological hypertrophy. These effects are modulated mainly via B-2 receptor activation," researchers in Sao Paulo, Brazil report.

"Chronic physical exercise can induce physiological cardiac hypertrophy characterized by normal organization of cardiac structure. Therefore, the aim of this work was to verify the influence of kinin B-2 receptor deletion on physiological hypertrophy to exercise stimulus. Animals were submitted to swimming practice for 5 min or for 60 min, 5 days a week, during 1 month and several cardiac parameters were evaluated. Results showed no significantly difference in heart weight...

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