Dilated Cardiomyopathy

New dilated cardiomyopathy study results reported from L. Zhang et al

Published in Cardiovascular Business Week, September 9th, 2008

"Circulating autoantibodies against the M2-muscarinic acetylcholine receptor (CHRM2) have been detected in patients with dilated cardiomyopathy (DCM). However, it has yet to be determined whether the pathogenesis of familial DCM may be linked to the genetic variability of the CHRM2 gene," scientists in Beijing, People's Republic of China report.

"The coding regions of the CHRM2 gene were examined by direct DNA sequencing. Plasma concentrations of autoantibodies against CHRM2 were determined by ELISA in 7 unrelated DCM families. Linkage analysis demonstrated cosegregation of the microsatellite markers, D7S509 and D7S495 that flank the CHRM2 gene, with the familial form...

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Source: Cardiovascular Business Week (2008-09-09)

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