Study results from Emory University, Carlyle Fraser Heart Center broaden understanding of perfusion

"This study tested the hypothesis that inhibition of myocardial injury and modulation of mitochondrial dysfunction by postconditioning (Postcon) after 24 h of reperfusion is associated with activation of K-ATP channels. Thirty dogs undergoing 60 min of ischemia and 24 h of reperfusion (R) were randomly divided into four groups: Control: no intervention at R; Postcon: three cycles of 30 s R alternating with 30 s reocclusion were applied at R; 5-hydroxydecanoate (5-HD): the mitochondrial K-ATP channel blocker was infused 5 min before Postcon; HMR1098: the sarcolemmal K-ATP channel blocker was administered 5 min before Postcon," scientists writing in the journal Basic Research in...

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