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Thrombosis

Researchers at Montreal General Hospital target thrombosis

Published in Cardiovascular Business Week, May 5th, 2009

"Anti-heat shock protein (HSP)60 autoantibodies are associated with atherosclerosis and are known to affect endothelial cells in vitro. However, their role in thrombus formation remains unclear," scientists in Montreal, Canada report.

"We hypothesized that anti-HSP60 autoantibodies could potentiate thrombosis, and evaluated the effect of anti-murine HSP60 antibodies in a ferric chloride (FeCl3)-induced murine model of carotid artery injury. Anti-HSP60, or control, IgG was administered to BALB/c mice 48 h prior to inducing carotid artery injury, and blood flow was monitored using an ultrasound probe. Thrombus formation was more rapid and stable in anti-HSP60 IGG-treated...

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