Life Sciences

Researchers at University of Amsterdam publish new data on life sciences

Published in Cardiovascular Business Week, September 15th, 2009

According to recent research published in the journal Circulation Research, "The atrioventricular (AV) node is a recurrent source of potentially life-threatening arrhythmias. Nevertheless, limited data are available on its developmental control or molecular phenotype."

"We used a novel AV nodal myocardium-specific reporter mouse to gain insight into the gene programs determining the formation and phenotype of the developing AV node. In this reporter, green fluorescent protein (GFP) expression was driven by a 160-kbp bacterial artificial chromosome with Tbx3 and flanking sequences. GFP was selectively active in the AV canal of embryos and AV node of adults,...

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Source: Cardiovascular Business Week (2009-09-15)

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