Abdominal Aortic Aneurysm

Research reports from GlaxoSmithKline provide new insights into abdominal aortic aneurysm

Published in Cardiovascular Business Week, September 22nd, 2009

In this recent report, researchers in the United States conducted a study "To evaluate the use of an ultrasmall superparamagnetic iron oxide (USPIO) contrast agent as a marker for the detection of macrophage in a preclinical abdominal aortic aneurysm animal (AAA) model. Osmotic pumps were implanted subcutaneously in apoE(-/-) mice for continuous infusion of Angiotensin II (Ang-II)."

"Weekly bright-blood gradient echo scans were performed on the suprarenal abdominal aorta to evaluate aneurysm development. Once an AAA was detected, animals were administered 1000 mu mol/kg of the USPIO contrast agent ferumoxtran-10 (Combidex ®) followed by in vivo scanning 24 h...

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Source: Cardiovascular Business Week (2009-09-22)

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