Atherosclerosis

New atherosclerosis findings from H. Ohkawara and co-researchers published

Published in Cardiovascular Business Week, February 23rd, 2010

According to a study from Fukushima, Japan, "The activation of RhoA and Rac1 is crucial for the pathogenesis of atherosclerosis. This study investigated the changes of unprocessed and mature forms of RhoA and Rac1 in the progression of atherosclerosis."

"Unprocessed and geranylgeranylated forms of RhoA and Rac1 in aortic atherosclerotic lesions were separated by the Triton X-114 partition method using Watanabe heritable hyperlipidemic (WHHLMI) rabbits prone to myocardial infarction. The activation of RhoA and Rac1 was determined by membrane translocation and pull-down assays. The levels of unprocessed RhoA and Rac1 of the aortas were higher at 7 months than 3 months,...

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Source: Cardiovascular Business Week (2010-02-23)

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