Hypertension

Data from University of Missouri, Medical Department provide new insights into hypertension

Published in Cardiovascular Business Week, February 23rd, 2010

According to recent research published in the American Journal of the Medical Sciences, "The lungs of patients with pulmonary arterial hypertension (PAH) exhibit decreased bioavailability of nitric oxide and downstream signaling through cyclic guanosine monophosphate (cGMP). Therapies that enhance cGMP-mediated vasodilation have shown efficacy in treating PAH."

"We tested the hypothesis that combination therapy with sildenafil, a cGMP phosphodiesterase type 5 inhibitor, and brain natriuretic peptide (BNP), a receptor-mediated guanosine cyclase stimulator, synergistically attenuates monocrotaline-induced PAH in rats compared with either monotherapy. Adult male...

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Source: Cardiovascular Business Week (2010-02-23)

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