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AstraZeneca

Apolipoprotein risk factors for CVD reviewed

Published in Cardiovascular Device Liability Week, March 21st, 2004

The apolipoprotein risk factors for cardiovascular disease have been reviewed.

"Although LDL cholesterol (LDL-C) is associated with an increased risk of coronary heart disease, other lipoproteins and their constituents, apolipoproteins, may play an important role in atherosclerosis," scientists in Sweden explained.

"Elevated levels of apolipoprotein (apo) B, a constituent of atherogenic lipoproteins, and reduced levels of apo A-I, a component of anti-atherogenic HDL, are associated with increased cardiac events," according to G. Walldius and colleagues at AstraZeneca. "Apo B, apo A-I and the apo B/apo A-I ratio have been reported as better predictors...

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