Royal Netherlands Academy of Arts & Sciences
MCIP1 overexpression preserves post-infarction cardiac function
Published in Cardiovascular Device Liability Week, April 4th, 2004
"Pathological remodeling of the left ventricle (LV) after myocardial infarction (MI) is a major cause of heart failure," scientists in the Netherlands explained. "Although cardiac hypertrophy after increased loading conditions has been recognized as a clinical risk factor for human heart failure, it is unknown whether post-MI hypertrophic remodeling of the myocardium is beneficial for cardiac function over time, nor which regulatory pathways play a crucial role in this process."
"To address these questions, transgenic (TG) mice engineered to overexpress modulatory...
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