Graz University of Technology

Activation of stress-linked muscle kinases analyzed, role of ceramide revealed

Published in Cardiovascular Device Liability Week, January 2nd, 2005

Researchers from the Netherlands have reported on the role of ceramide in the activation of stress-associated mitogen-activated protein kinases by minimally modified low-density lipoprotein in vascular smooth muscle cells.

"Interaction of oxidized low-density lipoprotein (LDL) with arterial smooth muscle cells (SMC) is believed to play a key role in the development of atherosclerosis. Depending on the extent of oxidation, apolipoproteins and/or lipids in the particle may be modified and thus lead to different cellular responses (e.g. proliferation or cell death)," wrote A. Loidl and colleagues, Graz University of Technology.

"Here we report on the...

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Source: Cardiovascular Device Liability Week (2005-01-02)

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