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Inst. fur Allgemeine & Spezielle Zoologie, Giessen

Action of 5-HT agonists on autonomously contractile compartments was studied

Published in Cardiovascular Device Liability Week, January 2nd, 2005

An antagonistic 5-HT receptor system in the auricles of the systemic heart complex of Sepia officinalis L. (Cephalopoda) shows 5-HT1 and 5-HT4 subtype properties.

According to a study from Germany, "In pharmacological bioassays on isolated ring-shaped auricle preparations of Sepia officinalis, the action of the specific 5-hydroxytryptamine (5-HT) agonists 8-OH-DPAT (5-HT1a ), CP-93129 (5-HT1b ), TFMPP (5-HT1b ) and RS-67333 (5-HT4 ) on these autonomously contractile compartments was studied."

T. Lehr and colleagues reported, "8-OH-DPAT and CP-93129 induced mainly...

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