Oregon State University

Inositol phosphate accumulation desensitized in vascular cells

Published in Cardiovascular Device Liability Week, January 2nd, 2005

Scientists from the United States have reported on the desensitization of anglotensin-stimulated inositol phosphate accumulation in human vascular smooth muscle cells.

"The effect of angiotensin II treatment on desensitization of phospholipase C (PLC)-mediated inositol phosphate accumulation has not been quantitated in human aortic vascular smooth muscle (HVSM) cells.

"We determined the angiotensin II pretreatment dose dependency and time course for desensitization of PLC activation in HVSM cells and the effect of protein kinase C (PKC) activators on angictensin II-mediated inositol phosphate accumulation," wrote T.M. Filtz and colleagues, Oregon...

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Source: Cardiovascular Device Liability Week (2005-01-02)

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