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St. Georg Hospital, Leipzig

Ethnicity commands the role of dopamine receptor gene in hypertension

Published in Cardiovascular Device Liability Week, March 6th, 2005

Ethnicity commands the role of dopamine receptor gene in hypertension.

"The dopamine receptor type 1 (DRD1) has been implicated in the development of hypertension in humans as well as in animal models of spontaneous hypertension. We screened the entire coding and promoter region of the human DRD1 receptor for polymorphisms to analyze their association with hypertension. The allele frequencies of two common single-nucleotide polymorphisms, A-48G and G-94A were determined in 493 hypertensive patients and 209 normotensive controls," investigators in Germany report.

"Allele frequencies did not differ for both polymorphisms between the two groups (-48...

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