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Florida State University

Key role of signal-transcribing gene during cell cycle discovered

Published in Cardiovascular Device Liability Week, November 6th, 2005

Biologists at Florida State University (FSU) have uncovered the pivotal role of a gene called "Cut" that acts as a sort of middleman in cell-to-cell communication.

A DNA-binding protein, Cut interprets and transcribes the developmental signals sent through the "Notch" gene, which regulates a layer of epithelial cells as they replicate and divide. But when Cut garbles those signals the result is uncontrolled cell proliferation, sometimes with dire genetic and health consequences.

Results of the study are described in the Oct. 1 edition of the journal Development.

Led by FSU assistant professor Wu-Min Deng, the research has...

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