Harvard Medical School
Cu2+-mediated oxidation of cholesterol may be common to atherosclerosis and Alzheimer disease
Published in Cardiovascular Device Liability Week, November 6th, 2005
According to scientists writing in the Journal of Clinical Investigation, "The abnormal accumulation of amyloid beta-peptide (A beta) in the form of senile (or amyloid) plaques is one of the main characteristics of Alzheimer disease (AD). Both cholesterol and Cu2+ have been implicated in AD pathogenesis and plaque formation."
L. Puglielli and colleagues of the Harvard Medical School wrote, "A beta binds Cu2+ with very high affinity, forming a redox-active complex that catalyzes H2 O2 production from O2 and cholesterol....
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