Aarhus University Hospital
Plasminogen activator inhibitor type 1 increased in HIV-associated lipodystrophy
Published in Cardiovascular Device Liability Week, November 13th, 2005
According to recent research published in the European Journal of Clinical Investigation, "PAI-1, an important inhibitor of fibrinolysis, is increased in obese subjects and has been shown to be an independent risk factor for cardiovascular disease.
"In the present study, we investigated the association between circulating levels of PAI-1 and locally produced PAI-1 in adipose tissue and body fat distribution and adipokines (TNF-alpha, TNF receptors, IL-6, IL-8) in patients with and without HIV-associated lipodystrophy syndrome (HALS)."
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