Austin Hospital, Melbourne
In septic shock, blockade of KATP channels does not have potent effect on vasomotor tone
Published in Cardiovascular Device Liability Week, May 21st, 2006
According to a study from Australia, "Marked potassium efflux prevents calcium entry into vascular smooth muscle cells and may be responsible for the 'vasoplegia' of septic shock. Blockade of adenosine triphosphate (ATP)-sensitive potassium channels restores vascular tone in animal studies of septic shock. The effect of such potassium channel blockade has not been previously studied in humans."
S. Warrillow and colleagues at Austin Hospital in Melbourne wrote, "[The objective was] to test whether the...
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