Korea University, South Korea
Spironolactone prevents diabetic nephropathy through anti-inflammatory mechanism
Published in Cardiovascular Device Liability Week, July 23rd, 2006
"Aldosterone induces myocardial fibrosis and vascular inflammation via proinflammatory and profibrotic cytokines. The effect of spironolactone on renal inflammation and renal function was investigated in type 2 diabetic rats. For define the molecular mechanism of spironolactone, the effect of spironolactone on the synthesis of monocyte chemotactic peptide-1 (MCP-1) and its upstream transcription factor, NF-kappa B, was evaluated in cultured mesangial cells and proximal tubular cells," scientists writing in the Journal of the American Society of Nephrology...
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