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Gene Therapy

Research from University of Barcelona, Cardiovascular Research Center in the area of gene therapy published

Published in Cardiovascular Device Liability Week, July 15th, 2007

Researchers detail in "Sterol regulatory element binding proteins downregulate LDL receptor-related protein (LRP1) expression and LRP1-mediated aggregated LDL uptake by human macrophages," new data in gene therapy. According to a study from Spain, "In the extracellular intima, extracellular matrix proteoglycans favor LDL retention and aggregation (agLDL). In contrast to native LDL (nLDL), agLDL induces high intracellular cholesteryl ester (CE) accumulation in macrophages."

"It has been suggested that LDL receptor-related protein (LRP1) is involved in agLDL binding and internalization by macrophages. The aim of this work was to analyze whether sterol regulatory element...

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