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Acute Lymphoblastic Leukemia

Study: Re-engineered Gleevec reduces heart risks

Published in Cardiovascular Device Liability Week, December 23rd, 2007

Dec. 3, 2007 – Using a new bottom-up approach for rational drug design, researchers at Rice University and the University of Texas M. D. Anderson Cancer Center have reengineered the powerful anticancer drug imatinib -- best known by its brand name Gleevec™ -- to more specifically target one type of cancer while potentially curbing a rare life-threatening cardiotoxic side effect.

The new study, which is slated to appear in the Dec. 3 issue of the Journal of Clinical Investigation, reports pre-clinical evidence that the newly re-engineered drug is just as effective as imatinib against gastrointestinal stromal tumor (GIST) and carries significantly less risk of heart...

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