Abdominal Aortic Aneurysm

Studies from University of Pennsylvania reveal new findings on abdominal aortic aneurysm

Published in Cardiovascular Device Liability Week, May 4th, 2008

According to a study from the United States, "Microsomal prostaglandin (PG) E-2 synthase-1 (mPGES-1) catalyzes isomerization of the cyclooxygenase product PGH(2) into PGE(2). Deletion of mPGES-1 modulates experimentally evoked pain and inflammation and retards atherogenesis."

"The role of mPGES-1 in abdominal aortic aneurysm is unknown. The impact of mPGES-1 deletion on formation of angiotensin II-induced abdominal aortic aneurysm was studied in mice lacking low-density lipoprotein receptor (LDLR-/-). Male mice deficient in both mPGES-1 and LDLR (mPGES-1(-/-) LDLR-/-) and littermate LDLR-/- mice were initiated on a high-fat diet at 6 months of age, followed 1 week later...

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Source: Cardiovascular Device Liability Week (2008-05-04)

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