Published in Cardiovascular Device Liability Week, May 4th, 2008
"The role of mPGES-1 in abdominal aortic aneurysm is unknown. The impact of mPGES-1 deletion on formation of angiotensin II-induced abdominal aortic aneurysm was studied in mice lacking low-density lipoprotein receptor (LDLR-/-). Male mice deficient in both mPGES-1 and LDLR (mPGES-1(-/-) LDLR-/-) and littermate LDLR-/- mice were initiated on a high-fat diet at 6 months of age, followed 1 week later...
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