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Reports from University of Michigan highlight recent research in life sciences

Published in Cardiovascular Device Liability Week, August 3rd, 2008

"Radiofrequency ablation therapy of atria[ fibrillation (AF) recently incorporated the analysis of dominant frequency (DF) and/or etectrogram fractionation for guidance. However, the relationships between DF, fractionation, and spatiotemporal characteristics of the AF source remain unclear," scientists in the United States report.

"We hypothesize that a meandering reentrant AF source contributes to the wave fractionation and is reflected in the power spectrum of local electrograms elsewhere in the rotor's surroundings. Meandering rotors as AF sources were simulated in 2-dimensional models of human atrial tissue and recorded in isolated sheep hearts. Nondominant elements...

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