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Heart Failure

Reports on heart failure findings from University of Cincinnati, Medical Department provide new insights

Published in Cardiovascular Device Liability Week, February 15th, 2009

"A human protein phosphatase inhibitor-1 polymorphism, G147D (c. 440G > A, p. 147G > D), has been previously demonstrated to blunt the contractile responses of cardiomyocytes to beta-adrenergic agonists. The present study sought to examine whether the G147D inhibitor-1 polymorphism may be associated with specific clinical characteristics of heart failure carriers," scientists writing in the journal Cardiology report.

"Clinical information of 963 heart failure patients was analyzed according to race, inhibitor-1 genotype, treatment with beta-blockers and mortality patterns. The G147D inhibitor-1 genetic variant was found almost exclusively in black subjects...

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