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Stem Cell Research

Study findings from University of Pittsburgh broaden understanding of stem cell research

Published in Cardiovascular Device Liability Week, April 19th, 2009

According to a study from the United States, "Vascular delivery of mesenchymal stem cells (MSCs) following myocardial infarction is under clinical investigation. Little is known about the microvascular fate of MSCs."

"We used intravital microscopy of rat cremaster muscle microcirculation to track intraarterially delivered MSCs. Rat MSCs ( average diameter, 23 mu m) were bolused into the ipsilateral common iliac artery. Interrogation of an arteriole-venule pair revealed that 92 +/- 7% ( n = 6) of MSCs arrest and interrupt flow during first pass at the precapillary level, resulting in decreased flow in the feeding arteriole ( velocity decreased from 6.3 +/- 1.0 to 4.6 +/-...

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